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Following phagocytosis and recognition of MSU crystals in the joints, IL-1β expression is induced by signaling pathways such as TLR, NOD-like receptor 3 (NLRP3), P2X purinoceptor 7 and mitogen-activated protein kinase pathways, among others, leading to an inflammatory response

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Similarly, PELATON (also known as LINC01272), one of the long non-coding RNA (lncRNA), induces ferroptosis and promotes cancer cell growth by down-regulating mutant p53 in CRC